MYB (gene)

V-myb myeloblastosis viral oncogene homolog (avian)

PDB rendering based on 1guu.
Identifiers
Symbols MYB; Cmyb; c-myb; c-myb_CDS; efg
External IDs OMIM: 189990 MGI: 97249 HomoloGene: 31311 GeneCards: MYB Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4602 17863
Ensembl ENSG00000118513 ENSMUSG00000019982
UniProt P10242 Q8BU24
RefSeq (mRNA) NM_001130172.1 NM_033597
RefSeq (protein) NP_001123644.1 NP_291075
Location (UCSC) Chr 6:
135.5 – 135.54 Mb		 Chr 10:
20.84 – 20.88 Mb
PubMed search [1] [2]

Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene.[1][2]

Contents

Function

Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis.[2]

References

  1. ^ Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X (Jul 2007). "The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells". Biochem Biophys Res Commun 360 (2): 433–6. doi:10.1016/j.bbrc.2007.06.078. PMID 17599807. 
  2. ^ a b "Entrez Gene: v-myb myeloblastosis viral oncogene homolog (avian)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4602. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.